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A SNARE required for retrograde transport to the endoplasmic reticulum

Authors
  • Lena Burri
  • Oleg Varlamov
  • Claudia A. Doege
  • Kay Hofmann
  • Traude Beilharz
  • James E. Rothman
  • Thomas H. Söllner
  • Trevor Lithgow
Publisher
National Academy of Sciences
Publication Date
Jul 31, 2003
Source
PMC
Keywords
Disciplines
  • Biology
License
Unknown

Abstract

SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) are central components of the machinery mediating membrane fusion in all eukaryotic cells. Sequence analysis of the yeast genome revealed a previously uncharacterized SNARE, SNARE-like tail-anchored protein 1 (Slt1). Slt1 is an essential protein localized in the endoplasmic reticulum (ER). It forms a SNARE complex with Sec22 and the ER syntaxin Ufe1. Down-regulation of Slt1 levels leads to improper secretion of proteins normally resident in the ER. We suggest that Slt1 is a component of the SNAREpin required for retrograde traffic to the ER. Based on the previously reported association with Ufe1 and Sec22, Sec20 likely contributes the fourth SNARE to the SNAREpin.

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