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A pneumococcal clinical isolate with high-level resistance to cefotaxime and ceftriaxone.

Authors
  • A M Figueiredo
  • J D Connor
  • A Severin
  • M V Vaz Pato
  • A Tomasz
Publication Date
Apr 01, 1992
Source
PMC
Keywords
Disciplines
  • Biology
  • Medicine
License
Unknown

Abstract

A beta-lactam-resistant serotype 23F Streptococcus pneumoniae clinical isolate from the cerebrospinal fluid of a pediatric patient from California is unusual in that the MICs of cefotaxime and ceftriaxone (2.5 micrograms/ml each) are higher than that of benzylpenicillin (0.3 micrograms/ml); the isolate also has patterns of penicillin-binding proteins and of cell wall peptides which are atypical compared with those of previously examined penicillin-resistant pneumococci.

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