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A bovine hemoglobin-based oxygen carrier as pump prime for cardiopulmonary bypass: reduced systemic lactic acidosis and improved cerebral oxygen metabolism during low flow in a porcine model.

Authors
  • McNeil, Jeffrey D1
  • Propper, Brandon
  • Walker, Joshua
  • Holguin, Lauren
  • Evans, Lauren
  • Lee, Kihak
  • Fox, Peter T
  • Michalek, Joel E
  • Baisden, Clinton E
  • 1 Department of Surgery, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA. [email protected]
Type
Published Article
Journal
The Journal of thoracic and cardiovascular surgery
Publication Date
August 2011
Volume
142
Issue
2
Pages
411–417
Identifiers
DOI: 10.1016/j.jtcvs.2010.11.017
PMID: 21641005
Source
Medline
License
Unknown

Abstract

The addition of HBOC-201 for cardiopulmonary bypass appears to improve oxygen use and minimize anaerobic metabolism. Cerebral oxygen use was preserved in the HBOC-201 group, even during decrease in blood flow. These findings support the reported improved oxygen-unloading properties of HBOC-201 and might provide a benefit during cardiopulmonary bypass.

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