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Role of prostaglandins in the antimyoclonic action of clonazepam

Authors
Journal
European Journal of Pharmacology
0014-2999
Publisher
Elsevier
Publication Date
Volume
71
Issue
1
Identifiers
DOI: 10.1016/0014-2999(81)90402-7
Keywords
  • Polyphloretin Phosphate
  • Prostaglandins
  • Myoclonus
  • Clonazepam
  • Serotonin
  • Indomethacin

Abstract

Abstract Possible involvement of prostaglandins (PG) in the antimyoclonic action of clonazepam was examined in the p,p′-DDT-animal model of myoclonus. PG synthesis inhibitors and the PG antagonist polyphloretin phosphate (PPP) counteracted the antimyoclonic action of clonazepam in mice. PGE 2 reduced DDT-induced myoclonus; this effect was blocked by PPP. Another antimyoclonic drug combination, L-5-hydroxytryptophan plus chlorimipramine, was not blocked by PPP or indomethacin. The antimyoclonic action of clonazepam may be mediated by enhancement of PG synthesis.

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