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Regulation of the immune response:II. Concomitant idiotope-specific enhancement and suppression can result in a phenotypically normal response

Authors
Journal
Cellular Immunology
0008-8749
Publisher
Elsevier
Publication Date
Volume
98
Issue
1
Identifiers
DOI: 10.1016/0008-8749(86)90275-3
Disciplines
  • Biology

Abstract

Abstract Idiotope-specific immunoenhancement or suppression was induced in C57BL/6 mice by the injection of physiological amounts (100 ng-10 μg) of monoclonal anti-idiotope antibody. As previously described, nanogram doses enhanced idiotope expression while a 10-μg dose of anti-idiotope antibody induced the activation of a population of Thy 1.2 +, Lyt 1 −, 2 + suppressors. Both positive and negative regulatory activities were confined to the non-μ, idiotope + compartment of the plaque-forming cell response. Administration of intermediate doses of anti-idiotope antibody resulted in an immune state indistinguishable from that of naive mice. This apparently normal response was in fact the product of a simultaneous activation of balanced enhancing and suppressive activities. When treated with anti-Lyt 2 or -Lyt 1 and complement, spleen cell populations taken from such phenotypically “naive” mice revealed latent idiotope-specific immunoenhancement or suppression, demonstrating the components of a functional regulatory equilibrium.

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