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The administration of maleic hydrazide and its diethanolamine salt to rats

Authors
Journal
Toxicology
0300-483X
Publisher
Elsevier
Publication Date
Volume
1
Issue
4
Identifiers
DOI: 10.1016/0300-483x(73)90036-x

Abstract

Abstract Groups each of 25 male and 25 female rats from a closed outbred Wistar Colony were injected subcutaneously with 2 mg of either maleic hydrazide (MH) or of its diethanolamine derivative (MH30), in either arachis oil or water, twice weekly for 65 weeks, and the animals maintained under observation for a further 39 weeks. In the group receiving MH in arachis oil there were 4 subcutaneous tumours, compared with 1 in the control group receiving arachis oil alone. There was no significant elevation of tumour incidence in rats receiving MH in water, or MH30 in either arachis oil or water, and none of the treatments appeared to affect the incidence of hepatic or mammary gland tumours. The results do not support the findings on a very small number of rats of the same strain employed by Dickens and Jones, nor those obtained by the technique of Epstein and his co-workers, but are in keeping with the findings of Barnes and his collaborators and support the safety-in-use of MH or MH30.

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