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Coupling a dynein transport model with a model of anterograde and retrograde transport of intracellular organelles

Authors
Journal
International Communications in Heat and Mass Transfer
0735-1933
Publisher
Elsevier
Publication Date
Volume
38
Issue
7
Identifiers
DOI: 10.1016/j.icheatmasstransfer.2011.04.024
Keywords
  • Fast Axonal Transport
  • Molecular Motors
  • Anterograde And Retrograde Transport
  • Modeling
  • Kinesin And Dynein Motors

Abstract

Abstract A model of fast axonal transport of organelles that accounts for dynein transport in an inactive state toward the axonal synapse is developed. It is assumed that anterograde transport of inactive dynein in an axon is powered by kinesin motors. It is further assumed that the probability of organelle attachment to a dynein motor is directly proportional to the concentration of free dynein motors available at a particular location in the axon. The results predicted by two models (the first one is that which incorporates dynein transport and the second one is the traditional model that does not incorporate dynein transport) are compared. The obtained results suggest that the availability of dynein motors in a particular location in an axon can be a factor limiting fast axonal transport.

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