Summary A hybrid odontogenic tumour comprising three distinct lesions is extremely rare. We presented a hybrid odontogenic tumour composed of a calcifying cystic odontogenic tumour (CCOT), a solid multicystic ameloblastoma (A-S/M) and an adenomatoid odontogenic tumour (AOT). This tumour was observed in the anterior area of the mandible of a 64-year-old Chinese woman. Masses of ghost epithelial cells with the characteristics of CCOT were seen in the lining of the cyst. The odontogenic epithelia with the features of A-S/M and AOT were also observed.