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Polarographic reduction of some potential antidiabetic compounds

Authors
Journal
Journal of Electroanalytical Chemistry
0022-0728
Publisher
Elsevier
Publication Date
Volume
84
Issue
1
Identifiers
DOI: 10.1016/s0022-0728(77)80236-2

Abstract

Abstract The polarographic reduction of 4-arylhydrazone-N′-benzysulphonyl-3-methyl-2-pyrazoline-5-ones gave two, two-electron transfer, well defined, well separated, diffusion controlled, irreversible waves in B.R. buffers of pH range 7.0–11.0. In acidic medium the E 1/2 values of the two waves are so close that only one 4-electron transfer, well defined, diffusion controlled, irreversible waves is obtained. The reduction in these compounds takes place at the-NH-N=C-bond. The effect of substituents and its correlation with the Hammett substituent constant (σ) have also been studied.

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