Affordable Access

Publisher Website

Bacterial infections: Bone and joint tuberculosis

Best Practice & Research Clinical Rheumatology
Publication Date
DOI: 10.1016/s1521-6942(06)80029-x
  • Medicine


Summary In many countries of the world, there is now a dual epidemic of tuberculosis and HIV disease. HIV specifically eliminates the tissue macrophages and CD4 lymphocytes, the very cells that provide immunity against tuberculosis. Tuberculosis is one of the more virulent opportunistic infections and it therefore appears fairly early in HIV disease. For the same reasons, bone and joint tuberculosis is becoming much more common. The disturbances of the lymphocyte count, ESR and antigen skin tests associated with HIV, now often make tuberculosis difficult to distinguish from other inflammatory lesions. The only change in the pattern of disease that we have so far registered is an increased incidence of disease affecting the lumbar spine. HIV-positive patients respond poorly to chemotherapy and are subject to drug sensitivity reactions. Major surgery is fraught with infectious complications and should be avoided. Once Pott's paraplegia has developed, the demise of the HIV-positive patient is rapid.

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times

More articles like this

Bacterial infections: bone and joint tuberculosis.

on Baillière s Clinical Rheumatol... February 1995

Bacterial infections: bone and joint tuberculosis

on Baillière s Clinical Rheumatol... Jan 01, 1995

Management of common bacterial infections of bones...

on The Journal of Bone and Joint... January 1967

[Bacterial sensitivity to antibiotics in bone and...

on Chirurgia narzadów ruchu i or... 1970
More articles like this..