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Reduction of thyroxine-induced necrotic foci and thrombi in the mouse liver by androgen, oestrogen and glucocorticoid but not by progesterone

Authors
Journal
Experimental and Toxicologic Pathology
0940-2993
Publisher
Elsevier
Publication Date
Volume
45
Identifiers
DOI: 10.1016/s0940-2993(11)80411-2
Keywords
  • Thyroid Hormone
  • Liver
  • Androgen
  • Oestrogen
  • Glucocorticoid
  • Thrombus
  • Progesterone
  • Thyroxine
  • Hepatic Lesion
  • Necrosis Hepatocellular
  • Hepatocellular Necrosis
  • Thyrotoxicosis
Disciplines
  • Biology
  • Pharmacology

Abstract

Summary Injections of thyroxine (T 4) at a dose of 10 μg/mouse/day into castrated adult female or male C57BL/6 mice for 3 weeks induced multiple necrotic foci and portal thrombi in the liver at high incidences. However, injections of T 4 into intact female or male mice resulted in the marked decrease in their incidences. Furthermore, injections of 5α-dihydrotestosterone at doses more than 50 μg/mouse/day, oestradiol-17β at doses of 0.2 and 1 μg/mouse/day or dexamethasone at doses more than 20 μg/mouse/day into castrated female mice markedly reduced incidences of necrotic foci and thrombi induced by T 4, while injections of progesterone did not show any effects on them. The present results indicate that an excess of thyroid hormone causes the hepatic impairment in castrated mice and that androgen and oestrogen at physiological doses, and glucocorticoid at pharmacological doses prevent it.

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