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Association study of theCFHY402H polymorphism with Alzheimer's disease

Authors
Publisher
Elsevier Inc.
Publication Date
Volume
31
Issue
1
Identifiers
DOI: 10.1016/j.neurobiolaging.2008.03.003
Keywords
  • Cfh
  • Alzheimer
  • Polymorphism
  • Prospective Study
  • Cross-Sectional Study
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Several reports indicated that Alzheimer's disease (AD) and age-related macular degeneration (AMD) may share similar genetic and pathological features. We postulated that the functional Y402H polymorphism within the CFH gene and unambiguously recognised as a major genetic determinant of AMD, may also be a risk factor of AD. We analysed the association of this polymorphism with the AD risk in both prospective and cross-sectional studies. We were not able to detect such an association whatever the studied population, suggesting that the CFH gene is not a genetic determinant of AD.

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