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Nerve growth factor mRNA and protein levels measured in the same tissue from normal and Alzheimer's disease parietal cortex

Authors
Journal
Molecular Brain Research
0169-328X
Publisher
Elsevier
Publication Date
Volume
42
Issue
1
Identifiers
DOI: 10.1016/s0169-328x(96)00193-3
Keywords
  • Nerve Growth Factor
  • Neurotrophic Factor
  • Basal Forebrain
  • Retrograde Transport
  • Neurodegeneration
  • Dot Blots
  • Elisa
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Nerve growth factor (NGF) mRNA and protein levels were determined in parietal cortex samples from both normal and Alzheimer's disease (AD) patients. NGF protein levels were slightly elevated in AD patients compared to controls, but NGF mRNA levels were unchanged in the same tissue samples. Thus, small but reproducible increases in NGF protein reported in AD cortex do not result from increases in NGF mRNA.

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