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Simple synthesis and separation of the diastereomers of α-thio analogs of ribo- and deoxyribo- di- and triphosphates

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
27
Issue
31
Identifiers
DOI: 10.1016/s0040-4039(00)84859-5

Abstract

Abstract Nucleoside 5′-0-(1-thiodi-) and triphosphates can be obtained in yields of up to 45% directly from the nucleosides. Their diastereomers can be separated by preparative reversed phase chromatography.

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