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The mammographic appearances of benign mammary mucocele-like lesions

BioMed Central Ltd.
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  • Biology
  • Ecology
  • Medicine


Available online S1 1 Molecular pathology of breast cancer SR Lakhani The Breakthrough Toby Robins Breast Cancer Research Centre, Institute of Cancer Research & The Royal Marsden Hospital, London, UK Abstracts from Symposium Mammographicum 2002 University of York, 17–19 July 2002 The multistep model of carcinogenesis in the breast suggests a transition from normal epithelium to invasive carcinoma via non-atypical and atypical hyperplasia and in situ carcinoma. The introduction of mammographic screening has led to the increased detection of preinvasive disease, and this has high- lighted deficiencies in the biology and classification of such lesions. The excitement surrounding the development of DNA microarray analysis and proteomics has raised expectations about the role of these techniques in understanding the biology and translating these data to clinical practice. Only a few years ago, scientists studied disease initiation and progression in a linear fashion, identifying and examining one cancer-related molecule at a time. The recent development of technologies that allow a large number of genes and gene products to be analysed simultaneously has brought renewed interest to breast cancer research, with the hope of identifying a unique ‘fingerprint’ for each tumour and hence individualised treat- ment. To date, histopathological assessment has been at the heart of clinical management – does the new technology herald the end? 2 Hormone replacement therapy (HRT): indications and side effects MI Whitehead Department of Obstetrics & Gynaecology, King’s College Hospital, London, UK Late submission, see page S22 The Collaborative Group on Hormonal Factors in Breast Cancer has brought together and reanalysed about 90% of the world- wide epidemiological evidence on the relation between risk of breast cancer and use of hormone replacement therapy (HRT). Data on 52,705 women with breast cancer and 108,411 women without breast cancer fr

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