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A Conserved Signal-Responsive Sequence Mediates Activation-Induced Alternative Splicing of CD45

Authors
Publisher
Elsevier Inc.
Publication Date
Volume
12
Issue
5
Identifiers
DOI: 10.1016/s1097-2765(03)00434-9
Disciplines
  • Biology

Abstract

Abstract Alternative splicing of nascent transcripts is a widespread mechanism for altering protein expression in response to extracellular stimuli. However, little is known about the sequences that mediate signal-induced alternative splicing, complicating efforts to identify genes whose splicing may be regulated in response to a particular stimuli. Here we define a sequence element that is both the primary determinant of CD45 variable exon exclusion following T cell stimulation by PMA and is sufficient to confer activation-induced skipping of a heterologous exon. Additionally, we show that this regulatory element has homology to sequences in other signal-regulated genes, suggesting that the alternative splicing of large families of genes may be regulated by common signaling pathways.

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