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Schistosoma mansoni:Effect of some cations on the proteolytic enzymes of cercariae

Authors
Journal
Experimental Parasitology
0014-4894
Publisher
Elsevier
Publication Date
Volume
35
Issue
2
Identifiers
DOI: 10.1016/0014-4894(74)90036-8
Keywords
  • Schistosoma Mansoni
  • Trematoda
  • Cercariae
  • Preacetabular Glands
  • Proteolytic Enzymes
  • Sephadex Gel Filtration
  • Calcium
  • Cations

Abstract

Abstract The effects of various salts on the proteolytic activity of extracts from Schistosoma mansoni cercariae were tested. Using an Azocoll substrate, stimulation (2 to 2.5-fold) of activity by the monovalent cations Na + and K + was demonstrated, with maximum stimulation at 20–40 m M concentrations. The divalent cations Mg 2+ and Ca 2+ stimulated proteolytic activity at low concentrations (between 0 and 10 m M) but inhibited activity at higher concentrations. The divalent cations Zn 2+, Cu 2+, Fe 2+, and Co 2+ were inhibitory even at very low concentrations. The results presented here are discussed in relation to previously described ion effects on cercarial infectivity.

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