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TNF-α and IFN-γ Down-Regulate the Expression of the Metastasis-Associated Bi-functional 37LRP/p40 Gene and Protein in Transformed Keratinocytes

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
251
Issue
2
Identifiers
DOI: 10.1006/bbrc.1998.9431
Keywords
  • 37 Lrp/P40
  • 67Lr
  • Bi-Functional
  • Metastasis-Associated
  • Tnf-α
  • Ifn-γ
Disciplines
  • Biology

Abstract

Abstract The 37 LRP/p40 molecule is a bi-functional protein in which expression is increased in a large variety of cancers in association with their metastatic phenotype. Here we present the first data concerning the 37 LRP/p40 gene promoter activity and show that it is very active in a cervix carcinoma cell line. Interestingly, despite hallmarks of a housekeeping gene, we show that the 37 LRP/p40 gene promoter can be down-regulated by two potentially anticancerous cytokines, TNF-α and IFN-γ. In addition, the dual fate of the protein, i.e., being intracellularly involved in the cell translation machinery and incorporated into a 67-kDa cell surface protein functioning as a laminin receptor (67LR), is differentially affected by the treatment. Our data suggest multiple regulation levels in the control of the 67LR/37LRP/p40 molecule expression and uncover new clues for the understanding of both the control of expression of this metastasis-associated molecule and the IFN-γ and TNF-α anticancerous action.

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