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NMDAR1-like immunoreactive fibers appear in the ipsilateral optic tract during optic nerve regeneration inRana pipiens

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
236
Issue
1
Identifiers
DOI: 10.1016/s0304-3940(97)00695-2
Keywords
  • Amphibian Visual System
  • Regeneration
  • N-Methyl-D-Aspartate
  • Optic Tract
  • Presynaptic
Disciplines
  • Medicine

Abstract

Abstract N-Methyl- d-aspartate receptor subunit 1-like immunoreactivity (NMDAR1-LI) was investigated in the brain of Rana pipiens during optic nerve regeneration. Following unilateral optic-nerve crush, frogs were tested for prey-catching and optokinetic nystagmus responses to assess return of visual function. At 1, 2, 3 and 5 months after the surgery, NMDAR1-LI was assessed in central visual pathways. At 3 and 5 months, conspicuous ipsilateral NMDAR1-LI fibers were detected in the thalamic and pretectal nuclei, and the time of their appearance coincided with the onset of behavioral recovery. Also, only ipsilateral retinorecipient layers in the optic tectum showed increased NMDAR1-LI during optic nerve regeneration. These results suggest that NMDA receptors may be present on retinal ganglion cell axons and terminals that have been misrouted during regeneration.

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