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Regulatory T cell kinetics in the peripheral blood of patients with Crohn’s disease

Authors
Journal
Human Immunology
0198-8859
Publisher
Elsevier
Volume
74
Issue
2
Identifiers
DOI: 10.1016/j.humimm.2012.10.021
Disciplines
  • Medicine

Abstract

Abstract Estimates of T regulatory cell populations in the periphery of patients with Crohn’s disease are confounded by disease activity and concomitant immunotherapeutic agents known to affect T cell proliferation and survival. We performed deuterium pulse/chase experiments in patients with quiescent Crohn’s disease on no immunotherapy and healthy control subjects to estimate T regulatory cell kinetics. Quantification of deuterated DNA isolated from T cell subsets over 10days was determined by mass spectrophotometry. We demonstrate enhanced proliferation within the T regulatory cell population from patients with Crohn’s disease when compared to non-T regulatory cells and T regulatory cells from healthy control subjects. We speculate that T regulatory cells isolated from the periphery of patients with Crohn’s disease experience persistent antigen stimulation resulting in excess proliferative rates.

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