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Methodology used to develop the AANS/CNS management of brain metastases evidence-based clinical practice parameter guidelines

Authors
Journal
Journal of Neuro-Oncology
0167-594X
Publisher
Springer-Verlag
Publication Date
Volume
96
Issue
1
Identifiers
DOI: 10.1007/s11060-009-0059-2
Keywords
  • Invited Manuscript
Disciplines
  • Medicine

Abstract

INVITED MANUSCRIPT Methodology used to develop the AANS/CNS management of brain metastases evidence-based clinical practice parameter guidelines Paula D. Robinson • Steven N. Kalkanis • Mark E. Linskey • P. Lina Santaguida Received: 7 September 2009 / Accepted: 8 November 2009 / Published online: 3 December 2009 � The Author(s) 2009. This article is published with open access at Springerlink.com Background Brain metastases, which occur in approximately 20–40% of individuals with systemic cancer, represent a significant cause of morbidity and mortality and overwhelm all other types of brain tumors in terms of incidence and public health impact [1]. Considerable research has focused on improving survival and quality of life for this patient population. Given the expanding knowledge base and the rapid emergence of new therapies, the American Associa- tion of Neurological Surgeons (AANS), the Congress of Neurological Surgeons (CNS), and the AANS/CNS Joint Tumor Section jointly funded an initiative to produce methodologically rigorous evidence-linked clinical prac- tice parameter guidelines on this topic. The overall objec- tive of this series of guideline papers is to provide the latest up-to-date evidence-based recommendations for the man- agement of patients with brain metastases centering on eight questions related to commonly encountered clinical scenarios (Tables 1, 2, 3). Accomplishment of this goal required undertaking a systematic review of the literature. The McMaster University Evidence-based Practice Center (EPC), which is an academic research unit partially funded by an EPC grant from the Agency for Healthcare Research and Quality (AHRQ), with specialized expertise in evidence-based medicine and the development of sys- tematic reviews, was contracted to performed the system- atic review in consultation with the guideline panel assembled for the initiative. The McMaster EPC also served as facilitators during the guidelin

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