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New myrsinol diterpenes fromEuphorbia proliferaand their inhibitory activities on LPS-induced NO production

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
22
Issue
11
Identifiers
DOI: 10.1016/j.bmcl.2012.04.052
Keywords
  • Euphorbia Prolifera
  • Myrsinol Diterpene
  • Inhibitory Activities On No Production
Disciplines
  • Chemistry

Abstract

Abstract A phytochemical investigation of the roots of Euphorbia prolifera led to the isolation of ten new myrsinol diterpenes, named euphorbialoids A–J (1–10), and two known analogues (11 and 12). Their structures were elucidated on the basis of extensive 1D and 2D NMR (COSY, HMQC, HMBC and NOESY) spectroscopic data analyzes, and the structures of 1 and 9 were confirmed by X-ray crystallography. The inhibitory activities on LPS-induced NO production of these diterpenes were evaluated and all the compounds showed inhibitory effects.

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