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Synthesis and antiretroviral evaluation of 3-alkyl 2-piperazinone nucleoside analogs

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
35
Issue
51
Identifiers
DOI: 10.1016/0040-4039(94)88507-9

Abstract

Abstract Glycosylation of 3-alkyl N 4-(3-hydroxypropyl) 2-piperazinones by protected 1- O-acetyl ribofuranoses produces nucleoside analogs in which the base is separated from the sugar by a hydrocarbon spacer arm. The preliminary in vitro test results against retroviruses seem promising for compounds bearing a long alkyl chain.

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