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Bioresorbable glass effect on the physico-chemical properties of bilayered scaffolds for osteochondral regeneration

Authors
Journal
Materials Letters
0167-577X
Publisher
Elsevier
Publication Date
Volume
89
Identifiers
DOI: 10.1016/j.matlet.2012.08.023
Keywords
  • Composite Scaffolds
  • Bilayered
  • Bioresorbable Glass
  • Gelatin
  • Osteochondral Bone
Disciplines
  • Engineering

Abstract

Abstract In this work, bilayered and bioresorbable composite scaffolds are developed with mechanical and functional properties for osteochondral tissue engineering. Porous scaffolds made of gelatin (G) and bioresorbable phosphate glass (I-CEL2) with different compositions (I-CEL2/G 0/100; 30/70; 70/30%w/w) were fabricated by freeze-drying. Samples were crosslinked using γ-glycidoxypropyltrimethoxysilane to improve mechanical strength and thermal stability. I-CEL2/G samples showed interconnected pores having an average diameter ranging from 139±5μm for I-CEL2/G 0/100 to 116±9μm for I-CEL2/G 70/30. GPTMS-crosslinking and the increase of I-CEL2 amount stabilized the composites to water solution, as shown by swelling tests. The compressive modulus increased by increasing I-CEL2 amount up to 7.6±0.5MPa for I-CEL2/G 70/30.

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