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Determination of partition coefficients of pyrido[1,2-a]pyrimidin-4-one derivatives by traditional shake, thin-layer chromatographic and gas—liquid chromatographic methods

Authors
Journal
Journal of Chromatography A
0021-9673
Publisher
Elsevier
Publication Date
Volume
252
Identifiers
DOI: 10.1016/s0021-9673(01)88398-9

Abstract

Abstract In the investigation of quantitative structure—activity relationships, one of the most important linear free-energy related parameters is the logarithmic value of water—1-octanol partition coefficients (log P) and π values derived from that. Partition coefficients of eighteen pyrido[1,2- a]pyrimidin-4-one compounds were measured for the water—1-octanol solvent system by spectrophotometric methods. R M values and corrected Δ I values of the compounds were also determined by thin-layer chromatographic and gas—liquid chromatographic methods, respectively. The excellent correlations found between these log P, R M and corrected Δ I values prove that liquid—liquid partition data can be obtained not only by thin-layer chromatography or high-performance liquid chromatography but also by gas—liquid chromatography.

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