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Associations between continuous measures of disease activity in adult RA and the pediatric ACR response measures: a secondary analysis of JIA data

Authors
Journal
Pediatric Rheumatology
1546-0096
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
6
Identifiers
DOI: 10.1186/1546-0096-6-s1-p121
Keywords
  • Poster Presentation
Disciplines
  • Medicine

Abstract

1546-0096-6-S1-P121.fm BioMed Central Page 1 of 1 (page number not for citation purposes) Pediatric Rheumatology Open AccessPoster presentation Associations between continuous measures of disease activity in adult RA and the pediatric ACR response measures: a secondary analysis of JIA data S Ringold2, Y Chon3 and NG Singer*1 Address: 1University Hospitals/Case Medical Center and Rainbow Babies and Children's Hospital, Cleveland, OH, USA, 2Children's Hospital & Regional Medical Center/University of Washington, Seattle, WA, USA and 3Amgen, Inc, Thousand Oaks, CA, USA * Corresponding author Objectives To measure correlations between the DAS, DAS28, Sim- plified Disease Activity Index [SDAI], and Clinical Disease Activity Index [CDAI]) and ACR responses; to determine validity of these measures in polyarticular-course juvenile idiopathic arthritis (polyJIA). Methods Retrospective analysis of 2 etanercept trials. Disease activ- ity was calculated at baseline, 3 mo, and 6 mo. Data were analyzed independent of treatment arm. Visits were clas- sified by highest level of pediatric ACR response. EULAR response levels were based on DAS/DAS28 values. Corre- lation coefficients were calculated between the above measures. Areas under the receiver operating characteristic curve assessed discriminative characteristics of each con- tinuous measure to the pediatric ACR response measures. Results Mean DAS, DAS28, CDAI, and SDAI were 3.7, 4.7, 30.8, and 36.4 respectively at baseline, corresponding to high disease activity levels for the DAS, CDAI and SDAI, and moderate for the DAS28. At 3 mo, mean values corre- sponded to low disease activity for the DAS/DAS28, and moderate for the CDAI/SDAI. At 6 mo, mean scores corre- sponded to low disease activity for the DAS/DAS28/CDAI, and moderate for the SDAI. Good EULAR response was seen at 3 and 6 mo. Correlation between the continuous outcome measures and the pediatric core set components was moderate to very good, with the closest correlatio

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