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Extended duration of the detectable stage by adding HPV test in cervical cancer screening

Nature Publishing Group
Publication Date
DOI: 10.1038/sj.bjc.6601355
  • Short Communication
  • Medicine


Short Communication Extended duration of the detectable stage by adding HPV test in cervical cancer screening ME van den Akker-van Marie*,1, M van Ballegooijen1, L Rozendaal2, CJLM Meijer2 and JDF Habbema1 1Department of Public Health, Erasmus MC, PO Box 1738, 3000 DR Rotterdam, The Netherlands; 2Department of Pathology, VU MC, Amsterdam, The Netherlands The human papillomavirus test (HPV) test could improve the (cost�) effectiveness of cervical screening by selecting women with a very low risk for cervical cancer during a long period. An analysis of a longitudinal study suggests that women with a negative Pap smear and a negative HPV test have a strongly reduced risk of developing cervical abnormalities in the years following the test, and that HPV testing lengthens the detectable stage by 2–5 years, compared to Pap smear detection alone. British Journal of Cancer (2003) 89, 1830 – 1833. doi:10.1038/sj.bjc.6601355 & 2003 Cancer Research UK Keywords: human papillomavirus; cervical cancer screening model ����������������������������� One of the possible uses of the human papillomavirus test (HPV) is in primary cervical cancer screening in addition to or instead of the current Pap smear (Cuzick et al, 1999a; Cuzick, 2000; Meijer and Walboomers, 2000). Introduction of HPV screening should be based on established (cost-) effectiveness. The (cost-) effectiveness of HPV testing is primarily determined by the duration of the detectable preclinical stage (the period from the HPV infection to clinical disease), and the sensitivity and costs of HPV testing. To estimate preclinical duration and sensitivity, longitudinal studies on the association between HPV infection and the development of neoplasias are necessary. Several large longitudinal screening studies have started, but no long- term results have been reported yet, although smaller longitudinal studies have been published (Rozendaal et al, 1996, 2000; Ho et al, 1998; Liaw et al, 1999). These studies differ with res

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