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1,4-syn-Asymmetric induction in the titanium-mediated aldol reactions of chiral methyl α-silyloxy ketones

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
51
Issue
6
Identifiers
DOI: 10.1016/j.tetlet.2009.12.046
Keywords
  • Stereoselective Reactions
  • Acetate Aldol Reactions
  • Titanium Enolates
  • Chiral Ketones
Disciplines
  • Design

Abstract

Abstract Good levels of 1,4- syn asymmetric induction are obtained in the TiCl 4-mediated aldol reaction of methyl α-silyloxy ketones with achiral aldehydes. Such methodology represents a new approach to the substrate-controlled acetate aldol reaction, which can be useful to design more efficient syntheses of natural products.

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