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Regulation of cellular membrane transport by the exocytotic insertion and endocytic retrieval of transporters

Authors
Journal
Trends in Biochemical Sciences
0968-0004
Publisher
Elsevier
Publication Date
Volume
8
Issue
4
Identifiers
DOI: 10.1016/0968-0004(83)90234-7

Abstract

Abstract A mechanism for the rapid, reversible modulation of cellular transport rates by hormones and other agents is the exocytotic insertion of transporter-containing vesicles into the plasma membrane and their endocytic removal. Considerable evidence indicates that this mechanism accounts for insulin stimulation of glucose transport in fat and muscle cells, for histamine stimulation of acid secretion in the stomach mucosa, and for vasopressin enhancement of water permeability across bladder and kidney epithelia. The characteristic features of this type of regulation are presented.

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