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Volumetric measurement of the hippocampus, the anterior cingulate cortex, and the retrosplenial granular cortex of the rat using structural MRI

Authors
Journal
Brain Research Protocols
1385-299X
Publisher
Elsevier
Publication Date
Volume
10
Issue
1
Identifiers
DOI: 10.1016/s1385-299x(02)00181-2
Keywords
  • Magnetic Resonance Imaging (Mri)
  • Volumetric Measurement
  • Hippocampus
  • Cingulate Cortex
  • Retrosplenial Granular Cortex
  • Ventricles
  • In Vivo
Disciplines
  • Medicine

Abstract

Abstract MRI imaging of the rodent brain is a rapidly growing field in the neurosciences. Relatively limited information is available for regional volume determination. The present paper describes a reliable method for the assessment of the hippocampus, the anterior cingulate cortex, the retrosplenial granular cortex and the ventricles in rats. MRI scans were acquired using a 7 T magnet. The anatomical sampling method was found to be highly reliable with an intra-rater reliability of greater than 0.93. The current protocol should facilitate future in vivo neuroimaging research using animal models of neurodegenerative diseases.

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