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Effect of selected pesticides on alkaline and acid phosphatase in the rat

Authors
Journal
Toxicology Letters
0378-4274
Publisher
Elsevier
Publication Date
Volume
12
Identifiers
DOI: 10.1016/0378-4274(82)90182-5

Abstract

Abstract A single oral dose of DDT (60.0 mg/kg), malathion (687.5 mg/kg), phosalone (60.0 mg/kg) and elsan (175.0 mg/kg) to adult male albino rats produced significant impairment in acid and alkaline phosphatase activities within 1 h of dosing. Renal and hepatic alkaline phosphatase activity was significantly inhibited in all cases, while treatment with malathion and phosalone resulted in an increase in intestinal alkaline phosphatase activity. Elsan induced an increase in acid phosphatase activity in liver, kidney and intestine whereas the response to DDT, malathion and phosalone was variable.

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