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Role of glutamate metabotropic receptors in long-term potentiation in the hippocampus

Authors
Journal
Seminars in Neuroscience
1044-5765
Publisher
Elsevier
Publication Date
Volume
7
Issue
2
Identifiers
DOI: 10.1006/smns.1995.0014
Disciplines
  • Biology

Abstract

Abstract Glutamate metabotropic receptors (mGluRs) are heterogenous G-protein-linked receptors widely distributed in the central nervous system. These receptors, which are coupled to several second messengers, modulate voltage-gated and receptor-operated channels and play an important role in synaptic plasticity, notably in the modulation of long-term potentiation (LTP). In this review, we briefly describe the different electrophysiological effects of mGluRs and discuss the two models which have been proposed in the literature to underline the role of mGluRs in LTP.

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