Affordable Access

Publisher Website

Effects ofd-(−)-aminophosphonovalerate on behavioral and histological changes induced by systemic kainic acid

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
87
Identifiers
DOI: 10.1016/0304-3940(88)90139-5
Keywords
  • Kainic Acid
  • N- Methyl- D-Aspartate(Nmda) Receptor
  • D-(−)-Aminophosphonovalerate (D(−)Apv)
  • Hippocampus
  • Seizure
  • Neurotoxicity

Abstract

Abstract In rats, the seizures induced by systemic kainic acid (KA) are followed by extensive neuronal damage, notably in the hippocampal region. We report that the specific N- methyl- d-aspartate (NMDA) receptor antagonist, d-(−)-aminophosphonovalerate (D(−)APV), given i.c.v. prior to or 2 h after i.p. KA injection markedly protected CA1 but not other hippocampal neurons against degeneration. In contrast, D(−)APV had no effect on KA-induced wet dog shakes or on behavioral seizures. We conclude that NMDA receptors participate in the neurotoxic but not in the behavioral effects of systemic KA.

There are no comments yet on this publication. Be the first to share your thoughts.