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Proceedings: B and T cell membrane markers in human leukaemias and lymphomata.

British Journal of Cancer
Nature Publishing Group
Publication Date
  • Research Article
  • Biology
  • Chemistry
  • Medicine


REPORT OF THE LEUKAEMIA RESEARCH FUND 279 on initial presentation. Thus, these relapses may be due to new occurrences of disease. These and other studies of leukaemias and lymphomata were described and the implica- tions of the results for the causes of the malignancies were discussed. Review Paper: FIAKLOW, P. J., July 4, 1974. The Origin and Development of Human Tumours Studied with Cell Markers. New Engl. J. Med., 291, 26. CULTURED LYMPHOBLASTOID LINES AS A MODEL FOR LEUKAEMIA/LYMPHOMA C. M. STEEL, M.R.C. Clinical and Population Cytogenetics Unit, Edinburgh. With certain notable exceptions, the lymphoblastoid cell lines established from biopsies of Burkitt's lymphoma appear, on cytogenetic and biochemical analysis to be representative of the tumour cells in this condition (Gripenberg, Levan and Clifford, 1969; Klein et al., 1968; Fialkow et al., 1971). Similar lines derived from other sources have the property of indefinite proliferation in vitro and may therefore provide a model for the study of at least some aspects of malignancy. Though little is yet known of the mech- anisms involved in the transition from normal lymphocyte to lymphoblastoid cell, there are consistent differences between the two cell types which may provide clues to the nature of the transformation process. Many established lines have a high level of steroid-binding protein which is also a characteristic of the malignant cells in acute lymphoblastic leukaemia. Preliminary data suggest however that the cytolytic effect of steroids on some lymphoblasts is not depen- dent solely on the presence of steroid recep- tors (Gailani et at., 1973; Lippmann, Berry and Thompson, 1974). Changes in the expression of surface antigens may have an important role in protection of the host against the proliferation of abnormal lymphoid cells in vivo (Golub et al., 1972; Steel et al., 1974). The antigenic changes have yet to be fully characterized but HL-A typing reveals both qualitative and quantitative alterations in the express

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