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One-pot, four-component reaction of isocyanides, dimethyl acetylenedicarboxylate, and cyclobutene-1,2-diones: a synthesis of novel spiroheterocycles

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
46
Issue
8
Identifiers
DOI: 10.1016/j.tetlet.2004.12.117
Keywords
  • Multicomponent Reactions
  • Isocyanides
  • Zwitterions
  • Dimethyl Acetylenedicarboxylate

Abstract

Graphical abstract Isocyanides, dimethyl acetylenedicarboxylate, and cyclobutene-1,2-diones react in one-pot to afford novel spirocyclic compounds with double insertion of the isocyanide.

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