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Effect of cis-diaminedichloroplatinum (II) (cis-DDP) on the intraeellular Na+/K+-ratio in K 562 leukemia cells as revealed by X-ray microanalysis

Authors
Journal
Experimental and Toxicologic Pathology
0940-2993
Publisher
Elsevier
Publication Date
Volume
44
Issue
5
Identifiers
DOI: 10.1016/s0940-2993(11)80247-2
Keywords
  • Cis-Diaminedichloroplatinum (Cis-Ddp)
  • Na+/K+-Ratio
  • Leukemia Cells
  • Erythroleukemic Cells
  • X-Ray-Microanalysis
  • Electrolytes
  • Ionic Content
  • Intracellular
  • K 562 Leukemia Cells
  • Cytostatic Action

Abstract

Summary Changes of intracellular ionic homeostasis are believed to play a role in the cytostatic action of cis-DDP. It has been observed by means of X-ray microanalysis that cis-DDP did not alter the intracellular Na +/K +-ratio of K 562 leukemia cells during incubation periods which lasted shorter than the average doubling time of the cells of nearly 15 h. After 24 h the treated cells displayed at least two main populations in the distribution histogram of the Na +/K +-ratio. The results indicated that the passage of cis-DDP through the plasma membrane by itself did not change the monovalent electrolyte balance at the early stage of its action in K 562 cells.

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