Affordable Access

99mTc-HMPAO single photon emission tomography in late life depression: a pilot study of regional cerebral blood flow at rest and during a verbal fluency task.

Authors
  • Philpot, M P
  • Banerjee, S
  • Needham-Bennett, H
  • Costa, D C
  • Ell, P J
Type
Published Article
Journal
Journal of Affective Disorders
Publisher
Elsevier
Publication Date
Aug 01, 1993
Volume
28
Issue
4
Pages
233–240
Identifiers
PMID: 8227759
Source
Medline
License
Unknown

Abstract

Relative regional cerebral blood flow (rCBF) was measured at rest and during a verbal fluency task in ten elderly patients with major depressive disorder and nine controls. At rest, depressed patients showed significant reductions in the cortico-cerebellar ratios of tracer uptake in the right and left parietal, left temporal and left occipital regions. During the task relative rCBF increased in patients such that these differences disappeared. Relative rCBF did not correlate with severity of depressed mood or endogenous features but did correlate positively with severity of psychotic symptoms. Frontal relative rCBF correlated negatively with somatic symptoms and anxiety.

Report this publication

Statistics

Seen <100 times