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Familial occurrence of nonobstructive, noninfectious vesicoureteral reflux with renal scarring

Authors
Journal
The Journal of Pediatrics
0022-3476
Publisher
Elsevier
Publication Date
Volume
86
Issue
6
Identifiers
DOI: 10.1016/s0022-3476(75)80213-7

Abstract

A family is described in which gross vesicoureteral reflux and renal scarring are present in the father and threesons, none with a history of urinary tract infection. Vesicoureteral reflux alone is present in an infant daughter. Father-to-son transmission of vesicoureteral reflux has not been previously reported. Autosomal dominant inheritance of the trait is suggested. The renal scarring noted in these patients may reflect generalized maldevelopment of affected renal units. The increasing recognition of vesicoureteral reflux as a familial trait suggests the need for evaluation of families in which vesicoureteral reflux is found in more than one member.

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