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Synthesis and SAR of 1,4,5,6-tetrahydropyridazines as potent cannabinoid CB1receptor antagonists

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
19
Issue
19
Identifiers
DOI: 10.1016/j.bmcl.2009.08.007
Keywords
  • Cannabinoid Cb1
  • Antagonist
  • Inverse Agonist
  • Scaffold Hopping
  • Tetrahydropyridazine

Abstract

Abstract The synthesis and structure–activity relationship studies of 1,4,5,6-tetrahydropyridazines are described. The target compounds 3– 5 represent a novel class of potent and selective CB 1 receptor antagonists.

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