Affordable Access

Malignant lesions in the ventral prostate of alloxan-induced diabetic rats

Authors
Publisher
Blackwell Publishing Ltd
Publication Date
Keywords
  • Prostate
  • Atrophy
  • Intra-Epithelial Neoplasia
  • Inflammation
  • Alloxan
  • Diabetes
  • Medicine And Health Sciences
Disciplines
  • Biology
  • Chemistry
  • Medicine

Abstract

The aim of this study was to evaluate the changes caused by chronic diabetes in the rat ventral prostate and to establish a correlation between diabetes and the development of prostatic lesions. Male rats received alloxan (42 mg/kg b.w.) to induce diabetes. Ninety days after diabetes diagnosis, animals were sacrificed and the ventral prostate was removed and prepared for general and immunohistochemical analyses. The total area showing different types of lesions was estimated. Diabetes led to a decrease in the body and prostatic weights, as well as in testosterone levels. The prostate morphology and stereology showed high variation in the diabetic group. Some animals had light changes; the great majority had an intense epithelial atrophy; and other rats showed premalignant and malignant lesions in the prostate. Such epithelial atrophy was, in some samples, combined with chronic inflammation, similar to proliferative inflammatory atrophy (PIA). The diabetic group also presented high incidence of prostatitis, adenocarcinoma and prostatic intra-epithelial neoplasia (PIN). Samples with adenocarcinoma had poorly differentiated acini with high levels of cellular proliferation and nuclear atypia. These lesions exhibited an invasive feature showing Bcl-2-positive cells and interruptions in the basement membrane. An association of PIA, PIN and adenocarcinoma was detected in one sample. Reduced androgen levels have a synergic effect to insulin dysfunction promoting negative effects in the rat prostate. Diabetic individuals had a high incidence of prostatitis, and this inflammation could stimulate the incidence of other forms of prostatic pathology.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Malignant lesions in the ventral prostate of allox...

on International journal of exper... August 2008

Vascular lesions in alloxan diabetic rats.

on A.M.A. archives of pathology August 1951

Anti diabetic effect of cherries in alloxan induce...

on Recent patents on endocrine, m... January 2012
More articles like this..