Affordable Access

Publisher Website

Hypothesis: Production of superoxide, hydrogen peroxide and hydroxyl radicals by phagocytic cells: A cause of chronic inflammatory disease?

Authors
Journal
Cell Biology International Reports
0309-1651
Publisher
Portland Press
Publication Date
Volume
6
Issue
6
Identifiers
DOI: 10.1016/0309-1651(82)90175-8
Disciplines
  • Biology
  • Ecology
  • Geography
  • Medicine

Abstract

Abstract 1. (a) Phagocytic cells produce oxygen radicals when exposed to opsonised bacteria or “foreign cells” generally. 2. (b) These oxygen radicals are an important part of the mechanism by which foreign particles are destroyed. 3. (c) Release of oxygen radicals and enzymes into the surrounding environment by phagocytic cells causes damage. I propose that chronic inflammatory disease, as illustrated by the autoimmune diseases, results when this damage gets out of hand. 4. (d) I further propose that excessive oxygen radical production due to environmental factors can initiate the autoimmune diseases.

There are no comments yet on this publication. Be the first to share your thoughts.