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IGM gammopathy and polyneuropathy react with an antigenic glycolipid present in human central nervous system

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
97
Identifiers
DOI: 10.1016/0304-3940(89)90160-2
Keywords
  • Igm Monoclonal Gammopathy
  • Central Nervous System Antigen
  • Immunodetection
  • Thin-Layer Plate
  • Glycolipid
Disciplines
  • Biology
  • Medicine

Abstract

Abstract An immunological mechanism may be responsible for the peripheral neuropathies associated with the IgM monoclonal gammopathies. Myelin-associated glycoprotein, and sulfated glucuronic acid-glycosphingolipids of the paragloboside type specific of peripheral nervous system (PNS), have been found to be targets for these antibodies. We report here on the presence of a glycolipid antigen present in central nervous system white matter in 7 of 12 patients with IgM monoclonal gammopathy and neuropathy whose IgM reacts also with the specific sulfated glycolipids of PNS. Immunodetection of the antibodies was performed on thin-layer plates after separation of the glycosphingolipids from peripheral nerve and white matter. The lipid antigen had a migration on thin-layer chromatography close to sulfogalactosylceramide but the sulfatide standard did not react with the monoclonal IgM.

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