Abstract The Reiss Screen for Maladaptive Behavior, an instrument used to identify mentally retarded persons with mental health problems, was evaluated with 89 mentally retarded adults. Reliability and validity of the Reiss Screen, as well as the relationship with subject characteristics, is reported for a Dutch population. Internal consistency on the total score was good and modest on most subscales. The subscale autism had inadequate internal consistency. Interrater reliability was low to modest. Further, the Reiss Screen had good criterion validity. Last, few relationships were found between Reiss Screen scores and subject characteristics.