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Actin and myosin from blood platelets or muscle are potent aggregating agents

Authors
Journal
Thrombosis Research
0049-3848
Publisher
Elsevier
Publication Date
Volume
8
Issue
3
Identifiers
DOI: 10.1016/0049-3848(76)90031-1
Disciplines
  • Biology

Abstract

Abstract Myosin and actin from white skeletal muscle, chicken gizzard or human bloo platelets were found to induce shape change and biphasic aggregation of platelets in platelet-rich plasma. These effects were possibly due to the ADP associated with the contractile proteins on the basis of: 1) the failure of platelets refractory to ADP to aggregate with actin and myosin; 2) the inhibition and reversal of aggregation by ATP; 3) the abolition by apyrase of the contractile proteins-stimulated platelet aggregation.

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