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Analysis of the centromeric regions of the human genome assembly

Authors
Journal
Trends in Genetics
0168-9525
Publisher
Elsevier
Publication Date
Volume
20
Issue
11
Identifiers
DOI: 10.1016/j.tig.2004.08.008

Abstract

The sequence of the human genome is not yet complete, and major gaps remain at the centromere region of each chromosome, which is comprised of repetitive α satellite DNA. In this article, we describe the sequences in the vicinity of the centromere that are included in the current genome assembly, analyze the ∼7 Mb of α satellite that have been assembled thus far and anticipate the nature of the sequences that remain to be accounted for.

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