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Sublancin is not a lantibiotic but an S-linked glycopeptide

Authors
Journal
Nature Chemical Biology
1552-4450
Publisher
Nature Publishing Group
Publication Date
Volume
7
Issue
2
Identifiers
DOI: 10.1038/nchembio.509
Source
Legacy
Keywords
  • Article
Disciplines
  • Biology

Abstract

Sublancin is shown to be an S-linked glycopeptide containing a glucose attached to a Cys residue, establishing a new post-translational modification. The activity of the S-glycosyl transferase was reconstituted in vitro and the enzyme is shown to have relaxed substrate specificity allowing the preparation of analogs of sublancin. Glycosylation is essential for its antimicrobial activity.

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