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Microwave-assisted amination of 3-bromo-2-chloropyridine with various substituted aminoethanols

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
51
Issue
30
Identifiers
DOI: 10.1016/j.tetlet.2010.05.021
Keywords
  • Microwave-Assisted Amination
  • 3-Bromo-2-Chloropyridine
  • Aminoethanol
  • Pyrido[1
  • 4]Oxazine

Abstract

Abstract A simple method for microwave-assisted amination of 3-bromo-2-chloropyridine with various substituted aminoethanols is described. The reaction was carried out under microwave irradiation conditions (at 180 °C for 1–2 h) and the result was superior in terms of conversion and yield when compared to that of the corresponding conventional heating conditions.

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