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An improved mechanical air puff stimulator that allows activation of a variety of endoepithelial receptors and is suitable for the study of reflexes in animals and humans

Authors
Journal
Journal of Neuroscience Methods
0165-0270
Publisher
Elsevier
Publication Date
Volume
77
Issue
2
Identifiers
DOI: 10.1016/s0165-0270(97)00116-7
Keywords
  • Endoepithelial-Triggered Reflexes
  • Air Puff Stimulator
  • Neuronal Responses
Disciplines
  • Chemistry

Abstract

Abstract Studies of endoepithelial-triggered reflexes, such as nasal respiratory reflexes, are difficult to carry out in humans without a non-traumatic and reliable stimulation device. The air puff stimulator described allows us to deliver air puffs of brief duration at various intensities, frequencies, and temperatures. The stimulation is non-traumatizing and non-nociceptive. We have successfully used it in animals as a source of specific stimuli to enable us to study central and peripheral neuronal responses evoked by activation of endonasal dynamically sensitive receptors. Immunohistochemical studies of the c- fos expression evoked during sneezing elicited by air puffs provided additional evidence for the specificity of this particular stimulation technique. We suggest that the use of such a non-traumatizing air puff stimulator could be extended to human studies. It might be particularly useful in developmental studies of endoepithelial-triggered reflexes such as those respiratory reflexes whose immaturity at birth can be life-threatening.

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