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Liquid-holding experiments with human lymphocytes:III. Experiments with G0 and G1 cells

Authors
Journal
Mutation Research Letters
0165-7992
Publisher
Elsevier
Publication Date
Volume
207
Issue
1
Identifiers
DOI: 10.1016/0165-7992(88)90010-3
Keywords
  • Liquid-Holding Experiments
  • Human Lymphocytes
  • Diepoxybutane
  • Methylnitrosourea
Disciplines
  • Chemistry

Abstract

Abstract Liquid holding (LH) experiments were performed with human peripheral lymphocytes treated in the GO (G0-LH) or the G1 (G1-LH) phase of the cell cycle with diepoxybutane (DEB) or methylnitrosourea (MNU). In the G0-LH system, treatment with DEB but not with MNU led to a lowering of the frequencies of sisterchromatid exchanges (SCE). In the G1-LH system treatment with both chemicals led to a lowering of the SCE frequencies during the LH. These results are concluded to mean that lesions induced by DEB but not by MNU can be repaired in GO cells and that G1 cells can repair both DEB and MNU induced lesions.

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