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A selective model of plasma protein catabolism

Authors
Journal
Journal of Theoretical Biology
0022-5193
Publisher
Elsevier
Publication Date
Volume
90
Issue
1
Identifiers
DOI: 10.1016/0022-5193(81)90124-7
Disciplines
  • Biology

Abstract

Abstract Recent data suggest that the catabolism of certain plasma protein could be a stepwise process, the actual breakdown selectively acting only on the molecules which have undergone a characteristic change. Based on this assumption a kinetic model of plasma protein catabolism is built up, giving the analytic expression for a catabolic curve. Assuming a relatively small fraction of the modified form, this expression fits the existing experimental data with the same accuracy range as the classical random breakdown curve. A testing criterion able to discriminate between the two possibilities is suggested and some particular cases are briefly discussed.

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